Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs
نویسندگان
چکیده
منابع مشابه
Evaluation of the pressor, cardiac, and renal hemodynamic properties of angiotensin II in man.
R ECENTLY, synthetic angiotensin II has become available for study. Page, Helmer, Braun-Menendez, and co-workers have demonstrated that this compound represents the reaction product of renin on the ao-globulin hypertensinogen. Intensive pharmacological studies conducted by the Cleveland group' 4i 3 and the Swiss have verified these observations that synthetic angiotensin I I is identical with t...
متن کاملPressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
Recently, a new derivative of angiotensin (Ang) II, called "Ang A," has been discovered to be present in plasma of healthy humans and, in increased concentrations, in end-stage renal failure patients. The objectives of the study were to investigate the blood pressure and renal hemodynamic responses to Ang A in normotensive and hypertensive rats and in genetically modified mice and the binding p...
متن کاملRegional Hemodynamic Effects
The effects of intravenous ouabain (G-strophanthin), 20 /ng/kg, on the superior mesenteric, renal, and external iliac beds were studied over a 30minute period in eight normal conscious dogs before, and in five of them after, cholinergic blockade and in six conscious dogs with heart failure produced by tricuspid avulsion and progressive pulmonary stenosis. Blood flows were measured with Doppler ...
متن کاملUrotensin II and cardiomyopathy in end-stage renal disease.
Circulating urotensin (UTN) is increased in patients with heart failure and in patients with renal diseases, and UTN antagonism is currently considered as a potential treatment for these conditions. Contrary to this contention, studies in end-stage renal disease suggest that, perhaps because of interference with sympathetic and NO systems, UTN may be cardioprotective. Therefore, we investigated...
متن کاملRenal effects of human urotensin-II in rats with experimental congestive heart failure.
BACKGROUND Urotensin II (U-II) and its receptor GPR-14 are expressed in the kidney and the cardiovascular system of various mammalian species. Recent studies suggested that the U-II/GPR-14 system is upregulated in patients with congestive heart failure (CHF). However, the involvement of the peptide in the alterations of renal function in CHF remains unknown. METHODS The effects of incremental...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.902.13